Small-Molecule Inhibitors of METTL3, the Major Human Epitranscriptomic Writer

The RNA methylase METTL3 catalyzes the transfer of a methyl group from the cofactor S-adenosyl-L-methionine (SAM) to the N⁶ atom of adenine. We have screened a library of 4000 analogues and derivatives of the adenosine moiety of SAM by high-throughput docking into METTL3. Two series of adenine derivatives were identified in silico, and the binding mode of six of the predicted inhibitors was validated by protein crystallography. Two compounds, one for each series, show good ligand efficiency. We propose a route for their further development into potent and selective inhibitors of METTL3.     

Catalytic combustion of methane over a highly active and stable NiO/CeO2 catalyst

In the last decades, many reports dealing with technology for the catalytic combustion of methane (CH₄) have been published. Recently, attention has increasingly focused on the synthesis and catalytic activity of nickel oxides. In this paper, a NiO/CeO₂ catalyst with high catalytic performance in methane combustion was synthesized via a facile impregnation method, and its catalytic activity, stability, and water-resistance during CH₄ combustion were investigated. X-ray diffraction, low-temperature N₂ adsorption, thermogravimetric analysis, Fourier transform infrared spectroscopy, hydrogen temperature programmed reduction, methane temperature programmed surface reaction, Raman spectroscopy, electron paramagnetic resonance, and transmission electron microscope characterization of the catalyst were conducted to determine the origin of its high catalytic activity and stability in detail. The incorporation of NiO was found to enhance the concentration of oxygen vacancies, as well as the activity and amount of surface oxygen. As a result, the mobility of bulk oxygen in CeO₂ was increased. The presence of CeO₂ prevented the aggregation of NiO, enhanced reduction by NiO, and provided more oxygen species for the combustion of CH₄. The results of a kinetics study indicated that the reaction order was about 1.07 for CH₄ and about 0.10 for O₂ over the NiO/CeO₂ catalyst.     

630℃超超临界二次再热塔式锅炉热力特性与壁温耦合计算研究

630℃超超临界火电技术作为下一代超超临界发电技术,对于煤炭资源的节约、发电机组的经济性以及环境改善,都显示了优越性。目前630℃超超临界锅炉的热力计算还缺乏相关研究。本文以某1000MW超超临界二次再热塔式锅炉布置方案为例,将锅炉管道、炉膛、高温受热面作为串联管路计算,在工质侧将热力计算与管路计算进行耦合建立数值分析模型。该计算模型能够同时得到比实现水动力和热力计算更精细的结果,对后续700℃工程持续优化提升做好技术储备。     

Standing Surface Acoustic Wave (SSAW)‐Based Fluorescence‐Activated Cell Sorter

Microfluidic fluorescence‐activated cell sorters (μFACS) have attracted considerable interest because of their ability to identify and separate cells in inexpensive and biosafe ways. Here a high‐performance μFACS is presented by integrating a standing surface acoustic wave (SSAW)‐based, 3D cell‐focusing unit, an in‐plane fluorescent detection unit, and an SSAW‐based cell‐deflection unit on a single chip. Without using sheath flow or precise flow rate control, the SSAW‐based cell‐focusing technique can focus cells into a single file at a designated position. The tight focusing of cells enables an in‐plane‐integrated optical detection system to accurately distinguish individual cells of interest. In the acoustic‐based cell‐deflection unit, a focused interdigital transducer design is utilized to deflect cells from the focused stream within a minimized area, resulting in a high‐throughput sorting ability. Each unit is experimentally characterized, respectively, and the integrated SSAW‐based FACS is used to sort mammalian cells (HeLa) at different throughputs. A sorting purity of greater than 90% is achieved at a throughput of 2500 events s^?1. The SSAW‐based FACS is efficient, fast, biosafe, biocompatible and has a small footprint, making it a competitive alternative to more expensive, bulkier traditional FACS.     

Cost Optimization of Partial Computation Offloading and Pricing in Vehicular Networks

Journal of Signal Processing Systems - For vehicles with limited computation resources offloading their computational tasks to a mobile edge computing (MEC) server has been studied in the past as...     

垂直轴风力机两种翼型气动性能比较研究

叶片是风力机最重要的组成部分,在不同的风能资源情况下,翼型的选择对垂直轴风力机气动特性有着重要的影响。文章分别以NACA0018翼型(对称翼型)和NACA4418翼型(非对称翼型)建立3叶片H型垂直轴风力机二维仿真模型。应用数值模拟的研究方法,从功率系数、单个叶片切向力系数等方面比较两种风力机模型在不同叶尖速比下的气动特性,并采用风洞实验数据验证了流场计算的准确性。CFD计算结果表明:在低叶尖速比下,NACA4418翼型风力机气动特性优于NACA0018翼型风力机,适用于低风速区域;在高叶尖速比下,NACA0018翼型风力机气动特性较好,适用于高风速地区。而且在高叶尖速比时,NACA0018翼型在上风区时,切向力系数平均值要高于NACA4418翼型,在下风区时,NACA418翼型切向力系数平均值高。该研究可为小型垂直轴风力机翼型的选择提供参考。     

BANQ餐厅 美国波士顿

正Banq餐厅位是一家新型餐厅,位于便士储蓄银行(Penny Savings Bank)旧大楼以前用来经营银行业务的大厅内。餐厅分成两个部分,前面区域面向华盛顿大街,设计成酒吧,后面的大厅则作为用餐区。然而,这个空间在z轴上以天花板和地面之间的另一个分区为中心进行设计。如果由于餐厅空间活动的多变性而需要保持灵活性——包括两个座位、四个座位和六个座位,以及与聚会和其他活动有关的座位     

对SINBAD屏蔽基准题实验的模拟验证

为了验证屏蔽基准题的准确性，进一步完善我国的标准基准题库，采用蒙特卡罗MCNP程序精细建模计算方法，针对SINBAD屏蔽基准题库，选取其中具有代表性的3例基准题对其准确性进行评估验证。结果表明，模拟计算得到的结果在误差允许的范围内，能够给其他自主软件提供数据验证支持，可将验证结果归入我国屏蔽基准题数据库。      

Design of delayed reconfigurable manufacturing system based on part family grouping and machine selection

To improve the convertibility of reconfigurable manufacturing system (RMS), the concept of delayed reconfigurable manufacturing system (D-RMS) was proposed. RMS and D-RMS are both constructed around part family. However, D-RMS may suffer from ultra-long system problem with unacceptable idle machines using generic RMS part families. Besides, considering the complex basic system structure of D-RMS, machine selection of D-RMS should be addressed, including dedicated machine, flexible machine, and reconfigurable machine. Therefore, a system design method for D-RMS based on part family grouping and machine selection is proposed. Firstly, a part family grouping method is proposed for D-RMS that groups the parts with more former common operations into the same part family. The concept of longest relative position common operation subsequence (LPCS) is proposed. The similarity coefficient among the parts is calculated based on LPCS. The reciprocal value of the operation position of LPCS is adopted as the characteristic value. The average linkage clustering (ALC) algorithm is used to cluster the parts. Secondly, a machine selection method is proposed to complete the system design of D-RMS, including machine selection rules and the dividing point decision model. Finally, a case study is given to implement and verify the proposed system design method for D-RMS. The results show that the proposed system design method is effective, which can group parts with more former common operations into the same part family and select appropriate machine types.